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Patients must have a dedicated line for alteplase (tpa) infusions Should serious bleeding in a critical location (e.g., intracranial, gastrointestinal, retroperitoneal, pericardial) occur, treatment with cathflo activase should be stopped and the drug should be withdrawn from the catheter. The infusion must not be stopped or interrupted for other medications.

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Alteplase works by converting plasminogen to plasmin. Tissue plasminogen activator (tpa) catheter refers to a specialized medical device used in the delivery of tpa, a thrombolytic agent that facilitates the breakdown of blood clots. Learn how to prepare and administer cathflo® activase® (alteplase)

Allow appropriate cathflo® dwell time before assessing catheter function

See full safety for more information. Indwelling tunneled pleural catheters (ipcs) are used regularly for recurrent pleural effusion management Catheter obstruction is not uncommon, often requiring intrapleural medications instillation (ie, alteplase) to restore flow.